Link: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001063
Description: WebApr 1, 2022 · Guideline-directed medical therapy (GDMT) for heart failure (HF) with reduced ejection fraction (HFrEF) now includes 4 medication classes that include sodium-glucose cotransporter-2 inhibitors (SGLT2i). 2. SGLT2i have a Class of Recommendation 2a in HF with mildly reduced ejection fraction (HFmrEF).
DA: 84 PA: 72 MOZ Rank: 1
Link: https://www.acc.org/latest-in-cardiology/articles/2022/03/08/18/51/pharmacologic-treatment-for-hfpef
Description: WebMar 8, 2022 · More recently, the sodium-glucose cotransport-2 inhibitors (SGLT2i) have emerged as promising therapies for HFpEF. First, the SGLT2i empagliflozin showed a reduction in the risk of composite CV death or total HF hospitalization in HF with LVEF >40%. This benefit was driven by a reduction in HF hospitalizations. gdmt
gdmtDA: 20 PA: 2 MOZ Rank: 80
Link: https://hfsa.org/sites/default/files/2022-04/ACC-AHA-HFSA-JCF-HFGuidelines-Top10.pdf
Description: WebGDMT for HFrEF includes 4 medication classes that include SGLT2i. SGLT2i have a 2a recommendation in HFmrEF. New recommendations for HFpEF for SGLT2i (2a), MRAs (2b) & ARNi (2b) Improved LVEF refers to HFrEF where LVEF is now >40%; these patients should continue HFrEF treatment.
DA: 51 PA: 60 MOZ Rank: 91
Link: https://www.jacc.org/doi/10.1016/j.jacc.2023.12.024
Description: WebMar 8, 2024 · Principle 1: GDMT is the foundation of HF care, and the GDMT with the highest expected benefit should be prioritized. Based on large, randomized trials for HFrEF, ARNI, evidence-based beta-blockers, mineralocorticoid antagonists, and SGLT inhibitors are first-line medications for all populations.
DA: 11 PA: 92 MOZ Rank: 39
Link: https://www.jacc.org/doi/10.1016/j.jacc.2023.03.393
Description: WebMany clinicians, when faced with the diagnostic option of diastolic stress testing or invasive hemodynamic measurements, may instead simply initiate GDMT for HFpEF (including diuretic therapy and a sodium-glucose cotransporter-2 inhibitor [SGLT2i], outlined in Section 7.1) to assess for symptomatic improvement. A therapeutic trial of GDMT is a ...
DA: 39 PA: 47 MOZ Rank: 67
Link: https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2023/04/17/16/40/2023-acc-expert-consensus-on-hfpef
Description: WebApr 19, 2023 · Target for glycosylated hemoglobin HbA 1c is <7-7.5% for individuals with lower comorbidity burden or less severe HF and HbA 1c target is <8-8.5% for more severe HF, higher comorbidity burden, and the elderly. SGLT2 inhibitors should be first line for diabetic HFpEF. Metformin may be considered if estimated glomerular filtration rate … gdmt
gdmtDA: 14 PA: 13 MOZ Rank: 24
Link: https://www.jacc.org/doi/10.1016/j.jacc.2021.12.012
Description: WebApr 1, 2022 · In patients who are at least 40 days post-MI with LVEF ≤30% and NYHA class I symptoms while receiving GDMT and have reasonable expectation of meaningful survival for >1 year, an ICD is recommended for primary prevention of sudden cardiac death (SCD) to reduce total mortality .
DA: 35 PA: 61 MOZ Rank: 6
Link: https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2022/03/29/19/53/2022-aha-acc-hfsa-heart-failure-guideline-gl-hf
Description: WebApr 1, 2022 · GDMT has expanded to include four classes: 1) renin-angiotensin system inhibition (RASi) with angiotensin receptor-neprilysin inhibitors (ARNi), angiotensin-converting enzyme inhibitors (ACEi), or angiotensin (II) receptor blockers (ARB) alone; 2) beta blockers; 3) mineralocorticoid receptor antagonists (MRA); and 4) sodium-glucose …
DA: 75 PA: 2 MOZ Rank: 34
Link: https://www.uptodate.com/contents/treatment-and-prognosis-of-heart-failure-with-preserved-ejection-fraction
Description: WebSep 28, 2023 · Therapy for patients with HF and elevated BNP — In patients with HFpEF (LVEF ≥50 percent) who have New York Heart Association (NYHA) class II to III symptoms and who have an elevated B-type natriuretic peptide level (BNP; ie, BNP >100 pg/dL or N-terminal pro-BNP [NT-proBNP] >300 pg/dL), we suggest treatment with both a sodium … gdmt
gdmtDA: 86 PA: 14 MOZ Rank: 8
Link: https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001062
Description: WebApr 1, 2022 · Guideline-directed medical therapy (GDMT) for heart failure (HF) with reduced ejection fraction (HFrEF) now includes 4 medication classes that include sodium-glucose cotransporter-2 inhibitors (SGLT2i).
DA: 59 PA: 76 MOZ Rank: 33
