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  • 1. Vemurafenib: the first drug approved for BRAF -mutant cance…

    nature.com

    Link: https://www.nature.com/articles/nrd3847

    Description: WEBOct 12, 2012 · Following a rapid clinical development path, vemurafenib (Zelboraf; Plexxikon/Roche) was approved for the treatment of BRAF -mutated …

    DA: 7 PA: 4 MOZ Rank: 19

  • 2. Vemurafenib - Wikipedia

    wikipedia.org

    Link: https://en.wikipedia.org/wiki/Vemurafenib

    Description: WEBIt is an inhibitor of the B-Raf enzyme and was developed by Plexxikon. [2] Mechanism of action. Vemurafenib causes programmed cell death in …

    DA: 67 PA: 66 MOZ Rank: 44

  • 3. BRAF and MEK Inhibitors: Use and Resistance in BRAF-Mutated Canc…

    nih.gov

    Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080616/

    Description: WEBWhile BRAF has been shown as an effective target in the MAPK/ERK pathway for several cancers where this pathway is aberrant, other selective …

    DA: 50 PA: 61 MOZ Rank: 73

  • 4. Paradox breaker BRAF inhibitors have comparable potency and MA…

    nih.gov

    Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456617/

    Description: WEBAug 8, 2020 · Paradox breaker BRAF inhibitors, such as PLX8394, are designed to inhibit RAF dimer formation. We analyzed whether paradox breakers …

    DA: 48 PA: 6 MOZ Rank: 47

  • 5. Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

    nejm.org

    Link: https://www.nejm.org/doi/full/10.1056/NEJMoa1002011

    Description: WEBAug 26, 2010 · PLX4032 (Plexxikon; RG7204, Roche Pharmaceuticals) is a potent inhibitor of BRAF with the V600E mutation.

    DA: 20 PA: 80 MOZ Rank: 52