Link: https://www.clinicalcorrelations.org/2021/01/15/antiemetics-and-qt-prolongation/
Description: WEBJan 15, 2021 · Peer Reviewed. Introduction. QT interval prolongation is a common side effect shared among the most effective antiemetic classes. The risk of QT prolongation is exacerbated by electrolyte abnormalities observed in patients with ongoing emesis, particularly hypokalemia.
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Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186277/
Description: WEBApr 1, 2020 · QT prolongation. The risk of prolonging the QT interval on the ECG is important to consider when prescribing antiemetic drugs. While the effect may not be significant in isolation, the risk of dysrhythmia increases with other risk factors affecting the QT interval, such as drugs, hypokalaemia and hypocalcaemia.
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Link: https://emcrit.org/ibcc/antiemetic/
Description: WEBAug 21, 2015 · Absence of QT prolongation (perhaps the greatest advantage). Longer half-life (~40 hours). Superior efficacy compared to ondansetron (especially the 8-mg dosing of ondansetron). 0.25 mg palonosetron IV is a commonly used dose for prevention of chemotherapy-induced nausea and vomiting.
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Link: https://www.ncbi.nlm.nih.gov/books/NBK534864/
Description: WEBJul 2, 2023 · StatPearls [Internet]. Show details. QT Prolonging Drugs. Khashayar Farzam; Vijai S. Tivakaran. Author Information and Affiliations. Last Update: July 2, 2023. Go to: Continuing Education Activity. The heart has an electrical system that allows it …
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Link: https://www.uptodate.com/contents/acquired-long-qt-syndrome-clinical-manifestations-diagnosis-and-management
Description: WEBFeb 6, 2023 · Samuel Asirvatham, MD. Deputy Editor: Susan B Yeon, MD, JD. Literature review current through: Jan 2024. This topic last updated: Feb 06, 2023. INTRODUCTION. The long QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram (ECG) ( waveform 1 ).
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Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237186/
Description: WEBOct 28, 2020 · When prescribing drugs associated with QT prolongation, three key factors should be considered: patient-related risk factors (eg, female sex, age >65 years, uncorrected electrolyte disturbances); the potential risk and degree of QT prolongation associated with the proposed drug; and co-prescribed medicines that could increase the risk of QT prol...
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Link: https://link.springer.com/content/pdf/10.1007/978-3-319-98343-1_38.pdf?pdf=inline%20link
Description: WEBQTc prolongation from routine doses of 4–8 mg of ondansetron is minimal and is unlikely to be clini-cally significant or cause a dangerous arrhythmia. A patient who receives a single dose of an anti-emetic does not require routine screening electro-lytes or an electrocardiogram (ECG).
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Link: https://pubmed.ncbi.nlm.nih.gov/36662566/
Description: WEBJan 20, 2023 · Medications associated with the greatest QTc prolongation were dofetilide (mean QTc difference 21.52, 95% CI 10.58-32.70 milliseconds), mexiletine (mean QTc difference 18.56, 95% CI 7.70-29.27 milliseconds), amiodarone (mean QTc difference 14.96, 95% CI 13.52-16.33 milliseconds), rifaximin (mean QTc difference 14.50, 95% CI 12.12 …
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Link: https://link.springer.com/content/pdf/10.1007/s11845-020-02291-7.pdf
Description: WEBAt the forefront is the potential to prolong the heart rate–corrected QT interval (QTc), thereby increasing the risk of drug-induced torsades de pointes (TdP) and resultant drug-induced sudden cardiac death (SCD).
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Link: https://www.uptodate.com/contents/acquired-long-qt-syndrome-definitions-pathophysiology-and-causes
Description: WEBSep 21, 2022 · After puberty in males, a QTc between 460 and 469 is borderline and ≥470 is considered prolonged. In post-pubertal females, 460 to 479 is borderline and ≥480 ms is considered prolonged. (See "Acquired long QT syndrome: Clinical manifestations, diagnosis, and management", section on 'ECG findings' .)
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